DIPEPTIDYL PEPTIDASE-4 INHIBITOR FOR TREATING TYPE 2 DIABETES MELLITUS, COMPOUNDS (VERSIONS) Russian patent published in 2020 - IPC C07D471/08 A61K31/4245 A61K31/439 A61P5/50 

FIELD: chemistry.

SUBSTANCE: invention relates to organic chemistry and specifically to novel compounds which are amides of beta-amino acids of stereoisomers of 3-azabicyclo[2.2.1]heptene-2-carbonitrile of formula (I), or pharmaceutically acceptable salts thereof, where R¹=H is hydrogen; C_1-5 – alkyl; R²=H is hydrogen; C_1-5 – alkyl; benzyl (C₆H₅-CH₂), substituted with one, two or three halogen atoms (F); R³=H is hydrogen; adamantyl, in which each carbon can have a substitute selected from: hydroxy (OH-); benzyl (C₆H₅-CH₂), in which there can be substitutes: hydroxy- (OH-) and one halogen (F). Invention also relates to amide of beta-amino acids of stereoisomers of 3-(3-azabicyclo[2.2.1]heptane-2-yl)-1,2,4-oxadiazole of formula II and amide of beta-amino acids of stereoisomers 5-(3-azabicyclo[2.2.1]heptan-2-yl)-1,2,4-oxadiazole of formula III, dipeptidyl peptidase-4 inhibitor based on said compounds. , I,

EFFECT: development of inhibitors of dipeptidyl peptidase-4 for treating patients with type 2 diabetes mellitus.

8 cl, 99 ex, 2 tbl