FIELD: organic chemistry, pharmaceutical compositions.
SUBSTANCE: invention relates to new (N-substitutes glycyl)-2-cyanopyrrolidines of formula I 
, wherein R is adamantly, substituted in 3- and/or 5-site with one or more substituents, selected from group including C1-C10-alkyl, OR1 (R1 is C1-C10-alkyl, C1-C8-alkanoyl, -CO-NR4R5, wherein R4 and R5 are independently from one another hydrogen, cyclohexyl, C1-C10-alkyl, phenyl optionally substituted with C1-C10-alkyl or C1-C10-alkoxy), in free form or in form of acid additive salt. Claimed compounds inhibit dipeptidyl-peptidase IV (DPP-IV) activity and useful in pharmaceutical composition for treatment of conditions mediated by DPP-IV, such as insulin-independent diabetes mellitus and obesity.
EFFECT: new pharmaceutical compounds inhibiting dipeptidyl-peptidase IV.
5 cl, 1 dwg, 4 tbl, 12 ex
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