METHOD FOR DETERMINATION OF DEGREE OF METABOLIC MATURITY OF HETEROTOPIC OSSIFICATES BY BIOCHEMICAL INDICES OF PATIENT'S BLOOD Russian patent published in 2017 - IPC G01N33/52 

FIELD: medicine.

SUBSTANCE: invention relates to field of medicine, namely to traumatology and orthopaedics, and can be applied for determination of degree of metabolic maturity of heterotopic ossificates. Essence of the method: before surgery of heterotopic ossificates character of their location and localisation is determined, then microhemocirculation index (MI, p.u. - perfusion units) of soft tissues in projection of patient's heterotopic ossificates is estimated. In case if measured characteristics of index of phosphorus-calcium exchange in patient's venous blood constitute in terms of alkaline phosphatase content more than 160-180 U/l, in terms of osteocalcin content more than 50-58 ng/ml, as well as if characteristic of marker of bone matrix formation (PINP) - N-terminal procollagen pre-peptide higher than 90 ng/ml even in case of isolated affection of one elbow or one knee joint, fact of presence of occurrence of active regenerative processes, testifying to incompleteness of osteoid formation, its mineralisation with maturation of spongy bone tissue of newly formed bone and, as a result about untimeliness of performance of stage of surgical ablation of formed heterotopic ossificates is stated. In case if measured indices of phosphorus-calcium exchange in patient's venous blood constitute by characteristic of marker of bone matrix formation (PINP) - N-terminal procollagen pre-peptide less than 76 ng/ml even in case of isolated affection of one elbow or one knee joint, by alkaline phosphatase content within 40-150 U/l, and by osteocalcin content within 11-46 ng/ml, fact of completeness of processes of osteoid formation, its mineralisation with formation and maturation of spongy bone tissue of newly formed bone, and also testifying to sufficiency of metabolic maturity of patient's heterotopic ossificates with arresting active metabolic processes in pathological focus, indices of which testify to advisability of carrying out stage of surgical ablation of formed heterotopic ossificates with recovery of functionally sufficient volume of movements in affected joint, is stated. The invention can be used in treatment of patients with forming heterotopic ossificates under conditions of trauma and orthopaedic, surgical and other hospitals.

EFFECT: application of the invention ensures sufficient accuracy of estimation of degree of maturity of heterotopic ossificates before their surgical ablation, provides earlier and more effective detection of fact of development of heterotopic ossification process, as well as provision of high self-descriptiveness for selection of individual tactics of surgery of heterotopic ossificates.

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