METHOD FOR DETERMINING DEGREE OF METABOLIC MATURITY OF HETEROTOPIC OSSIFICATES PRIOR TO SURGICAL MANAGEMENT THEREOF Russian patent published in 2014 - IPC A61B6/00 A61B6/03 A61B5/145 

FIELD: medicine.

SUBSTANCE: surgical management of the heterotopic ossificates is preceded by analysing the patient's venous blood, and also describing and localising the ossificated by standardised X-ray imaging, multi-layer spiral CT and magnetic resonant tomography. Non-invasive laser Doppler flowmetry is used in a sitting or lying patient after a 30-minute rest with a sensor placed on the patient's skin in a projection of the heterotopic ossificates for 360-420 seconds at red laser light wavelength 0.63 mcm and probe volume 0.8-0.9 mm³ with applying spectral wavelet analysis of the blood flow oscillation to measure any sequences and to evaluate microhaemocirculation (perfusion units) of the soft tissues in a projection of the patient's heterotopic ossificates that describes general, i.e. capillary and extracapillary, average steady microvascular perfusion, and is proportional to an erythrocyte count and average linear rate in a probed volume; the range of spectral wavelet frequency oscillation amplitudes 0.0095-1.6 Hz is examined to specify and record the blood flow oscillation amplitudes of the proper myogenic origin within the frequency range of 0.07-0.145 Hz directly describing the nutritive passage of the examined tissues in a projection of the heterotopic ossificates. If the measured microhaemocirculation of the soft tissues in a projection of the heterotopic ossificates makes 0.5-1.8 perfusion units, the measured nutritive blood flow makes 0.3-1.0 perfusion units, while the wavelet spectrum of the blood flow oscillations within the frequency range of 0.07-0.145 Hz shows no myogenic oscillations, or the amplitude is negligible, then the processes of osteoid formation and mineralisation in a combination with formation and maturation of a spongy bone tissue of the new bone are stated to be completed, and an adequacy of the metabolic maturity of the patient's heterotopic ossificates is evidenced that testifies to advisability of the surgical management of the formed heterotopic ossificates. If the measured microhaemocirculation of the soft tissues in a projection of the heterotopic ossificates makes more than two perfusion units, the measured nutritive blood flow makes more than one perfusion unit, while the wavelet spectrum of the blood flow oscillations within the frequency range of 0.07-0.145 Hz shows predominant myogenic oscillations, the presence of active regenerative processes is stated that testifies to the fact that the processes of osteoid formation, mineralisation, as well as maturation of the spongy bone tissue of the new bone are incomplete that gives reasons to consider the surgical removal of the formed heterotopic ossificates to be premature.

EFFECT: method enables the objective assessment of the nature of the heterotopic ossification preceding the surgical management of the heterotopic ossificates.

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