METHOD FOR PREDICTION OF DEGREE OF RISK OF POLYCYSTIC OVARIAN SYNDROME FORMATION IN ADOLESCENT GIRLS Russian patent published in 2017 - IPC A61B5/00 G01N33/48 

FIELD: medicine.

SUBSTANCE: invention can be used to predict the risk of polycystic ovarian syndrome (PCOS) formation in adolescent girls. As anamnestic data assess the presence of: hereditary burden on PCOS by both mother and father, burdened family history of type 2 diabetes, burdened heredity for obesity are estimated. The presence of each attribute is scored as 2 points. Also the presence of low ≤2800 g or high ≥4000 g body weight of the child at birth at mature gestation term, maternal gestational diabetes during pregnancy, excess of the mother's body weight during pregnancy, chronic tonsilogenous infections and frequent sore throats, traumatic brain injury, history of neuroinfection, sedentary lifestyle, severe psychoemotional stress in the girl are determined. If present, the attributes are scored as 1 point each. Among the clinical data the presence of: menstrual irregularities in the type of oligo-/amenorrhea for more than 1.5-2 years after menarche, anovulatory cycle, obesity - body mass index (BMI) more than 30 kg/m², hirsutism is estimated. The presence of each attribute is scored as 3 points. If there is an excess of body weight with a BMI of 26-30 kg/m², abdominal redistribution of fat deposits, borderline hairiness - 8-14 points on the Ferriman-Gallwey scale, increased greasiness of hair and skin, acne, seborrhea, negroid acanthosis, fibrocystic mastopathy, 2 points are assigned to each feature. 1 point is assigned to the presence of normal body weight, dysfunctional uterine bleeding in the puberty period. Laboratory indicators are identified: in the presence of an increase in the ratio of luteinizing hormone to follicle stimulating hormone (LH/FSH) of more than 2.5, 3 points are assigned. Also, the presence of an elevated level of luteinizing hormone, an increased level of total testosterone, an elevated level of androstenedione, an increase in insulin with an empty stomach, an increased level of glycosylated hemoglobin are also determined. If present, each indicator is scored as 2 points. If there is an increase in the anti-Mullerian hormone level above the age limit, 1 point is assigned. The echographic signs are determined: ovaries volume is more than 10 cm³, at least 12 cystic-atreducing follicles with a diameter of 2-9 mm, the presence of which is scored as 3 points. In the presence of multifollicular ovaries 1 point is assigned. The derived points are summed up. With a score of 1-15, low risk of polycystic ovary syndrome formation is indicated. The total score of 31-54 points shows a moderate degree of risk. The total score of 32-62 points - a high degree of risk of polycystic ovarian syndrome formation.

EFFECT: method allows to predict polycystic ovarian syndrome formation in adolescent girls objectively, effectively, simply and at an early stage by evaluating the complex of the most significant indicators.

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