METHOD FOR DETERMINING LEVEL OF ENDOLYMPHATIC HYDROPS IN MENIERE DISEASE, SELECTION OF TREATMENT STRATEGY AND EVALUATION OF ITS EFFICIENCY Russian patent published in 2017 - IPC A61B5/55 A61K31/573 A61K49/06 A61P27/16 A61P31/04 

FIELD: medicine.

SUBSTANCE: group of inventions consists of a method for determining the level of endolymphatic hydrops (EHL), a method for selecting the EHL treatment strategy, and a method for evaluating the EHL treatment efficacy in Meniere disease. The patient is intratympanically injected with 1 ml of eightfold diluted contrast agent (CA). 24 hours after MRI with a magnetic field strength of 3 Tesla and 8-channel coil is carried out. The obtained data are used to assess the accumulation of CA and its value in the vestibule and semicircular canals. In the absence of CA accumulation in the vestibule and semicircular canals, a significant vestibular and canal hydrops is determined. If the CA accumulation is less than 50% of the area of the vestibule and if the CA is absent in the semicircular canals, a moderate vestibular and significant canal hydrops are determined. If the CA accumulation is more than 50%, but less than 70% of the area of the vestibule and the CA is present at less than 50% of the area of the semicircular canals, a small vestibular and moderate canal hydrops are determined. If the CA accumulation in the semicircular canals and in vestibule is more than 50%, but less than 70% of the area, an insignificant canal and insignificant vestibular hydrops are determined. If the CA accumulation in the vestibule and semicircular canals is more than 70% of the area, the absence of the hydrops is determined. The EHL treatment strategy is determined taking into account the revealed level. If a significant vestibular and canal hydrops are detected, dehydration therapy is carried out. If a moderate vestibular and significant canal hydrops are detected, dehydration therapy is carried out. If an insignificant vestibular and moderate canal hydrops are detected, dehydration therapy or intratympanic gentamycin treatment is carried out. If an insignificant vestibular and insignificant canal hydrops are detected, an intratympanic gentamycin treatment is carried out. To evaluate the EHL treatment efficacy in Meniere disease, the second MRI is performed to assess the CA accumulation and its value in the vestibule and semicircular canals. If the CA accumulation area is increased, the conducted treatment is considered to be effective.

EFFECT: accurate and objective assessment.

4 cl, 1 ex