FIELD: chemistry.
SUBSTANCE: invention relates to biochemistry, in particular to a humanized neutralizing monoclonal antibody selectively binding human interferon-beta and capable of neutralizing its biological activity, as well as to an isolated DNA fragment coding a light chain segment, and an isolated DNA fragment coding a heavy chain region. Also disclosed is an antigen-binding fragment of said monoclonal antibody.
EFFECT: invention enables effective neutralization of biological activity of human interferon-beta.
4 cl, 4 dwg, 6 tbl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| MONOCLONAL ANTIBODY CAPABLE OF NEUTRALIZING BIOLOGICAL ACTIVITY OF HUMAN INTERFERON BETA 1A | 2018 |
|
RU2729391C2 |
| MONOCLONAL ANTIBODY TO HUMAN INTERFERON BETA-1A | 2018 |
|
RU2728696C2 |
| RECOMBINANT Fab-scFv BASED ON A NEUTRALISING ANTIBODY AGAINST HUMAN BETA-1A INTERFERON AND AN ANTIBODY AGAINST HUMAN ErbB2 RECEPTOR | 2019 |
|
RU2748953C1 |
| HUMANISED ANTIBODY AND ANTIGENBINDING FRAGMENT (Fab), WHICH BINDS WITH HUMAN INTERFERON-γ, DNA FRAGMENTS CODING CLAIMED ANTIBODY AND ANTIGEN-BINDING FRAGMENT, CELL, TRANSFORMED BY DNA FRAGMENT, AND METHOD OF OBTAINING CLAIMED ANTIBODY AND ANTIGEN-BINDING FRAGMENT | 2013 |
|
RU2539752C2 |
| VARIABLE DOMAINS OF LIGHT AND HEAVY CHAIN OF THE MOUSE MONOCLONAL ANTIBODY AGAINST INTERFERON ALPHA (IFN-α) HUMAN ANTIGEN BINDING FRAGMENTS (FAb) AGAINST HUMAN IFN-α COMPRISING SAID DOMAINS | 2018 |
|
RU2694672C1 |
| HUMANISED ANTIGEN-BINDING FRAGMENTS (Fab) AGAINST RABIES VIRUS, ISOLATED DNA FRAGMENT, CODING Fab AGAINST RABIES VIRUS, YEAST CELL, TRANSFORMED BY DNA FRAGMENT, AND METHOD OF OBTAINING Fab AGAINST RABIES VIRUS WITH APPLICATION OF YEASTS | 2010 |
|
RU2440412C2 |
| MONOCLONAL ANTIBODY, LINKING WITH E-BIR VIRUS GLOBE-PROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY AND ANTIGEN-BINDING FRAGMENT | 2016 |
|
RU2644334C2 |
| MONOCLONAL ANTIBODY, BINDING WITH EBOLA VIRUS GLYCOPROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2015 |
|
RU2639533C2 |
| MONOCLONAL ANTIBODY, BINDING WITH EBOLA VIRUS GLYCOPROTEIN, DNA FRAGMENTS CODING THIS ANTIBODY, AND ANTIGEN-BINDING FRAGMENT | 2015 |
|
RU2630304C2 |
| VARIABLE DOMAINS OF LIGHT AND HEAVY CHAINS OF MURINE MONOCLONAL ANTIBODIES AGAINST HUMAN ALPHA-DEFENSINS 1-3 (HNP 1-3), ANTIGEN-BINDING FRAGMENTS (FAB) AGAINST HUMAN HNP 1-3, CONTAINING SAID DOMAINS | 2019 |
|
RU2724733C1 |
