METHODS AND APPARATUS FOR SYNTHESIZING IMAGING AGENTS, AND INTERMEDIATES THEREOF Russian patent published in 2017 - IPC C07D237/14 A61K51/04 C07B59/00 B01J19/00 

FIELD: chemistry.

SUBSTANCE: invention relates to methods of synthesis of an imaging agent having a formula presented below, and its precursors. In said formula R¹ denotes alkyl; R² denotes hydrogen or halogen; W is -O-CH₂; R³ is alkyl substituted with ¹⁸F isotope, alkoxyl substituted with ¹⁸F isotope, or alkoxyalkyl, substituted with ¹⁸F isotope, and n is equal to 1. Methods can ensure high output and large-scale synthesis in automated systems of imaging agents containing radioisotope ¹⁸F, which can be used as sensors, diagnostic tools, including for assessing blood supply, including myocardial blood supply.

EFFECT: methods can ensure high output and large-scale synthesis in automated systems of imaging agents containing radioisotope ¹⁸F, which can be used as sensors, diagnostic tools, including for assessing blood supply, including myocardial blood supply.

16 cl, 13 dwg, 21 tbl, 49 ex