TAGGED MOLECULAR VISUALISING AGENTS, METHODS FOR PREPARING AND METHODS FOR USING Russian patent published in 2014 - IPC A61K49/00 A61K51/04 A61K101/00 C07B59/00 C07C323/58 

FIELD: medicine.

SUBSTANCE: invention refers to a visualising agent for visualisation of cell oxidative stress in vivo and a precursor compound for a synthesis of the visualising agent. The agent contains a tagged cystine compound having a structure I: wherein one of R and R' contains a tag specified in a fluorescent tag representing Bodipy, or a radioactive tracer specified in ¹¹C, ¹³N, ¹⁵O, ¹⁷F, ¹⁸F, ⁷⁵Br, ⁷⁶Br, ¹²⁴I, ¹²³I, ¹³¹I and ⁷⁷Br, and the other of R and R' represents hydrogen. Also, the invention refers to a method for visualising a biological sample having a cystine/glutamate transporter with the method involving administering the above visualising agent into the above biological sample through the cystine/glutamate transporter.

EFFECT: invention provides the method for detecting oxidative stress in vivo in apoptotic cells by administering the visualising agent in a cystine/glutamate cell antiporter.

14 cl, 10 dwg, 6 ex