FIELD: medicine, pharmaceutics.
SUBSTANCE: claimed invention relates to radiopharmaceutical composition for determination of presence, localisation and/or quantity of one or more amyloid deposits on an organ or area of subject's body. Claimed composition contains compound of formula
:
Z represents S, NR', O or C(R')2, where each R' independently represents H or C1-6alkyl, Y represents hydrogen, halogeno, OR' or SR', (R1 = H or C1-6alkyl), or Y represents -NR1R2; and each R1-10 is independently selected from group, consisting of hydrogen, C1-6alkyl, C2-6alkenyl, C2-6alkinyl, C1-6alcoxy, C4-6cycloalkyl, hydroxyl, C1-6hydroxyalkyl, C2-6hydroxyalkenyl, C2-6hydroxyalkinyl, thiol, C1-6thioalkyl, C2-6thioalkenyl, C2-6thioalkinyl, C1-6thioalkoxy, halogeno, C1-6halogenoalkyl, C2-6halogenoalkenyl, C2-6halogenoalkinyl, C1-6halogenoalkoxy, amino, C1-6aminoalkyl, C2-6aminoalkenyl, C2-6aminoalkinyl, C1-6aminoalkoxy, cyano, C1-6cyanoalkyl, C2-6cyanoalkenyl, C2-6cyanoalkinyl and C1-6cyanoalkoxy; nitro, C1-6nitroalkyl, C2-6nitroalkenyl, C2-6nitroalkinyl and C1-6nitroalkoxy. Composition also contains biocompatible carrier-medium and 0.05-5.0% wt/vol of polysorbate at pH from 4.0 to 10.5. One atom of said formula I compound represents radioactive isotope, suitable for visualisation in vivo. Also claimed is method of obtaining said radiopharmaceutical composition.
EFFECT: invention ensures reduced loss of derivatives of thioflavin derivatives and high radioactivity.
22 cl, 5 ex
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