FIELD: chemistry.
SUBSTANCE: invention relates to the improved method for extracting nalmefene hydrochloride [17-(cyclopropylmethyl)-4,5-alpha-epoxy-6-methylenimorphinan-3,14-diol hydrochloride] from aqueous compositions containing nalmefene and certain impurities including nalmefene hydrochloride and naltrexone, which comprises the steps (a) mixing an aqueous composition comprising nalmefene hydrochloride and naltrexone with a bisulfite salt or with a suitable salt forming a bisulfite anion in an aqueous medium, (b) cooling the mixture produced in step (a), (c) isolating nalmefene hydrochloride from an aqueous suspension containing bisulfite adduct of naltrexone and solid nalmefene hydrochloride, (d) recovering solid nalmefene hydrochloride from the mixture produced in step (c).
EFFECT: method improvement.
10 cl, 1 tbl, 4 ex
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