METHOD FOR PRODUCING SODIUM SALT OF (2S,5R)-2-CARBOXAMIDO-7-OXO-6-SULFOOXY-1,6-DIAZABICYCLO[3,2,1]OCTANE Russian patent published in 2017 - IPC C07D471/08 

Abstract RU 2632192 C2

FIELD: chemistry.

SUBSTANCE: invention relates to a process for producing sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy-1.6-diazabicyclo[3.2.1]octane (of the formula (I), comprising: (a) reacting a compound of the formula (II) with a 1-hydroxybenzotriazole: ammonia complex in the presence of water as a solvent to prepare a compound of the formula (III); (b) hydrogenolysis of a compound of the formula (III) to obtain a compound of the formula (IV); (c) sulfonating a compound of the formula (IV) to obtain a compound of the formula (V) and (d) converting a compound of the formula (V) to a compound of the formula (I).

EFFECT: ease of implementation, low fire hazard.

7 cl, 1 dwg, 1 ex

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RU 2 632 192 C2

Authors

Gupta Sunil Vishnubkhagvan

Dzhadkhav Sunil Bkhaginat

Rane Vipul

Deshpande Prasad Keshav

Bkhavsar Satish

Jeole Ravindra Dattatraya

Patel Makhesh Vitkhalbkhaj

Dates

2017-10-03Published

2013-10-12Filed