FIELD: chemistry.
SUBSTANCE: invention relates to a process for producing sodium salt of (2S, 5R)-2-carboxamido-7-oxo-6-sulfooxy-1.6-diazabicyclo[3.2.1]octane (of the formula (I), comprising: (a) reacting a compound of the formula (II) with a 1-hydroxybenzotriazole: ammonia complex in the presence of water as a solvent to prepare a compound of the formula (III); (b) hydrogenolysis of a compound of the formula (III) to obtain a compound of the formula (IV); (c) sulfonating a compound of the formula (IV) to obtain a compound of the formula (V) and (d) converting a compound of the formula (V) to a compound of the formula (I).
EFFECT: ease of implementation, low fire hazard.
7 cl, 1 dwg, 1 ex
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Authors
Dates
2017-10-03—Published
2013-10-12—Filed