FIELD: chemical or physical processes.
SUBSTANCE: invention relates to a method of producing a compound of formula (I). Method comprises (a) treating a compound of formula (II) with ammonia to obtain a compound of formula (III) and (b) treating the product obtained in step (a) with 9-fluorenylmethyl chloroformate to protect a nitrogen atom in a piperidine ring, adding N,N-carbonyldiimidazole as a carbonylation agent and adding diethylamine to remove protection from the nitrogen atom in the piperidine ring. Invention also relates to a method of producing trans-7-oxo-6-sulphoxy-1,6-diazabicyclo[3.2.1]octane-2-carboxamide, which involves obtaining a compound of formula (I) using said method and treating the obtained compound by hydrogenation and treatment with a SO3 complex.
EFFECT: disclosed methods enable to obtain desired products with high output and sufficient purity.
4 cl, 5 ex
| Title | Year | Author | Number |
|---|---|---|---|
| (2S,5R)-5-[(BENZYLOXY)AMINO]PIPERIDINE-2-CARBOXAMIDE | 2012 |
|
RU2610091C2 |
| BETA-LACTAMASE INHIBITORS | 2009 |
|
RU2445314C9 |
| BETA-LACTAMASE INHIBITORS AND THEIR USE | 2018 |
|
RU2815314C2 |
| METHOD OF PRODUCING CHIRAL DERIVATIVES OF TERT-BUTYL 4-((1R,2S,5R)-6-(BENZYLOXY)-7-OXO-1,6-DIAZABICYCLO[3.2.1]OCTANE-2-CARBOXAMIDO)PIPERIDINE-1-CARBOXYLATE | 2014 |
|
RU2689339C2 |
| BETA-LACTAMASE INHIBITORS AND APPLICATION THEREOF | 2018 |
|
RU2753401C2 |
| OPTICALLY ACTIVE DIAZABICYCLOOCTANE DERIVATIVE AND METHOD FOR PRODUCTION THEREOF | 2011 |
|
RU2591701C2 |
| CRYSTALLINE FORMS OF DIAZABICLOCTANE DERIVATIVE AND A METHOD OF THEIR PRODUCTION | 2014 |
|
RU2801220C2 |
| CRYSTALLINE FORMS OF DIAZABICYCLOOCTANE DERIVATIVE AND METHOD FOR PRODUCTION THEREOF | 2014 |
|
RU2695219C2 |
| NOVEL BETA-LACTAMASE INHIBITOR AND METHOD FOR PRODUCTION THEREOF | 2013 |
|
RU2693898C2 |
| NEW β-LACTAMASE INHIBITOR AND A METHOD OF ITS PRODUCTION | 2019 |
|
RU2800050C2 |
