SUBSTITUTED TRIAZOLOPYRIDINES AND THEIR APPLICAION AS TYROSINE THREONINE KINASE (TTK) INHIBITORS Russian patent published in 2017 - IPC C07D471/04 A61K31/437 

FIELD: chemistry.

SUBSTANCE: invention relates to a compound of general formula (I) where R¹ means where * indicates the place of this group attachment to the rest of the molecule; R² means where * indicates the place of this group attachment to the rest of the molecule; R³ means a hydrogen atom; R⁴ means a hydrogen atom; R⁵ means a hydrogen atom; R^5a means a group selected from (C₁-C₄)-alkoxy-, halo-(C₁-C₄)-alkoxy groups; R^5b means a group selected from -C(═O)N(H)R⁸ , -C(=O)NR⁸R⁷, -N(R⁷)C(=O)OR⁸, R⁷-S(=O)_2-; R⁶ means , where * indicates the place of this group attachment to the rest of the molecule; R⁷ means a (C_1-C₃)-alkyl group; R⁸ means a hydrogen atom or a (C_1-C₆)-alkyl group. This (C₁-C₆)-alkyl group is optionally substituted once or repeatedly by a halogen atom; or R⁷ and R⁸ together with the moiety of the molecule to which they are attached, represent a 4 to 6-membered heterocyclic ring which is optionally substituted once or repeatedly by the same or different halogen atom; R⁹ means a group selected from (C_1-C₃)-alkyl, hydroxy-(C_1-C₃)-alkyl group, -N(H)R⁸; and Q is CH. The invention also relates to methods for the preparation of a general formula (I) compound, application of the compound of the invention as an Mps-1 kinase inhibitor, and application of the compound of the general formula (7) for preparation of a compound of the general formula (I).

EFFECT: new compounds of general formula I having the properties of Mps-1 kinase inhibitor are obtained.

10 cl, 99 ex, 8 tbl