SUBSTITUTED DERIVATIVES OF 4-AMINOCYCLOHEXANE Russian patent published in 2014 - IPC C07D209/12 C07D209/14 C07D401/04 C07D251/48 C07D251/54 C07C211/40 C07C233/36 C07C233/46 C07C311/18 C07D211/62 C07D213/12 C07D213/82 C07D309/08 A61K31/137 A61K31/404 A61K31/53 A61P25/00 A61P9/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to novel compounds of general formula (1), which possess affinity for µ-opioid receptor and ORL1-receptor, to medications, containing said compounds, and to application of said compounds for obtaining medications, suitable for treating pain, fear, stress and other diseases or conditions. In general formula (1) Y₁, Y₁', Y₂, Y₂', Y₃, Y₃', Y₄ and Y₄' stand for -H; R₁ and R₂ independently on each other stand for -H or -CH₃; on condition that R₁ and R₂ both simultaneously do not stand for -H; Q stands for: -C_6-16-aryl, non-substituted or mono- or poly-substituted with -F, -Cl, -Br or -I; or heteroaryl; R₃ stands for: -C_1-8-alkyl, non-substituted or mono- or poly-substituted -OR₀, where R₀ stands for non-substituted -C_1-3-alkyl; non-substituted -C_3-6-cycloalkyl-C_1-4-alkyl; non-substituted -C_1-4-alkyl-C_3-6-cycloalkyl; -C_6-16-aryl, non-substituted or mono- or poly-substituted with -F, -Cl, -Br, -I, -CN, -R₀ or -OR₀, where R₀ stands for non-substituted -C_1-8-alkyl; or heteroaryl; n stands for 0; X stands for -NR_A-; R_A stands for -H or -R₀; where R₀ stands for non-substituted -C_1-4-alkyl; and R_B stands for -C(=O)R₀; where R₀ stands for non-substituted -C_2-8-alkenyl-C_6-16-aryl or non-substituted -C_1-8-alkyl-(C_6-16-aryl)_1-2.

EFFECT: obtaining compounds for obtaining medications, suitable for treatment of pain, fear, stress and other diseases or conditions.

10 cl, 14 tbl, 164 ex