SUBSTITUTED DERIVATIVES OF 4-AMINOCYCLOHEXANE Russian patent published in 2014 - IPC C07D209/12 C07D209/14 C07D401/04 C07D251/48 C07C211/40 C07C233/36 C07C233/46 C07C311/18 C07D211/62 C07D213/12 C07D213/82 C07D251/54 C07D309/08 A61K31/137 A61K31/404 A61K31/53 A61P25/00 A61P9/00 

FIELD: chemistry.

SUBSTANCE: invention relates to novel compounds of general formula (1), which possess an affinity to the µ-opiod receptor and the ORL1-receptor. The invention also relates to the application of the said compounds for obtaining medications, which can be used in treatment of fear, stress and associated with stress syndromes, depressions, epilepsy, Alzheimer's disease, senile dementia, general cognitive dysfunctions, learning and memory disorders (as nootropic), withdrawal syndromes, alcohol and/or drug abuse and/or abuse of medications and/or alcohol, narcotic and medication addiction, etc. In general formula (1) (1) Y₁, Y₁ ^', Y₂, Y₂ ^', Y₃, Y₃ ^', Y₄ and Y₄ ^' in each case stand for -H; Q stands for -R₀, -C(=O)-R₀, -C(=O)OR₀, -C(=O)NHR₀, -C(=O)N(R₀)₂ or-C(=NH)-R₀; R₀ in each case stands for -C_1-8-aliphate, -C_3-12-cycloaliphate, -aryl, -heteroaryl, -C_1-8-aliphate-C_3-12-cycloaliphate, -C_1-8-aliphate-aryl, -C_1-8-aliphate-heteroaryl, -C_3-8-cycloaliphate-C_1-8-aliphate, -C_3-8-cycloaliphate-aryl or -C_3-8-cycloaliphate-heteroaryl; R₁ and R₂ independently on each other stand for -C-_1-8-aliphate; R₃ stands for -C_1-8-aliphate, -aryl, -heteroaryl or -C_1-8-aliphate-C_3-12-cycloaliphate; n stands for 0; X stands for -NR_A-;R_A stands for -C_1-8-aliphate; R_B stands for -C_1-8-aliphate; on condition that R₁, R₂, R_A and R_B simultaneously do not stand for the non-substituted-C_1-8-aliphate.

EFFECT: increased efficiency of the application of the compounds.

9 cl, 11 tbl, 164 ex