FIELD: pharmacology.
SUBSTANCE: sustained-release pharmaceutical composition includes potassium asparaginate hemihydrate, magnesium asparaginate dihydrate, matrix-forming polymer, which is an Eudragit polymer, ethyl cellulose, polyvinylpyrrolidone or a combination thereof, a disintegrant such as aerosil, methylcellulose, hydroxypropylmethylcellulose or hydroxypropyl cellulose, an antifriction substance that is talc or starch in the amounts indicated in the claims. The composition is in the form of a solid dosage, preferably in the form of a pill. The composition is characterized by an immediate onset of release and a prolonged, sustained maintenance of the active substances concentration for 12 hours. The pill core can be coated. What is also presented is a method for pharmaceutical composition production.
EFFECT: expanded arsenal of drugs used in cardiology and sports medicine, the composition of the invention provides a reduction in the frequency of drug intake, its manufacturing technology is economically advantageous.
23 cl, 2 dwg, 1 tbl, 2 ex
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