FIELD: medicine; pharmaceutics.
SUBSTANCE: invention provides a solid oral dosage form (hereinafter – SODF) prolonged releasing active pharmaceutical substance (hereinafter – APS) in the upper part of the stomach, while APS is characterized by an acidity constant indicator (pKa) from 0 to 7, and it relates to one of classes: BCS 1 or BCS4. APS delivery system contains water-insoluble organic polymer and auxiliary substances selected from a group consisting of water-soluble organic polymer, glidant, and lubricant.
EFFECT: possibility of controllable change in time of SODF presence in the stomach in a wide range, for example from 2 to 24 h, for APS with significantly different solubility and bioavailability properties, which allows for reduction in a number of taking a drug and provision of a uniform release profile without peak growth of systemic APS concentration.
2 cl, 7 dwg, 6 tbl, 4 ex
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