FIELD: pharmacology.
SUBSTANCE: invention relates to methods for preparation of intermediate aminosulfonic compounds for the synthesis of 2-[1-(3-ethoxy-4-methoxyphenyl)-2-methylsulfonylethyl]-4-acetylaminoisoindoline-1,3-dione, which is useful for prevention or treatment of diseases or conditions, associated with an abnormally high level or activity of TNF-α. And also to a method for preparation of (S)-1-(3-ethoxy-4-methoxyphenyl)-2-methanesulfonylethylamine.
EFFECT: increased efficiency.
26 cl, 2 ex
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