IMIDAZOPYRIDINE DERIVATIVES FOR USING IN THERAPY AS MEDICINAL AGENT INHIBITING PROTON PUMP AND INTERMEDIATE COMPOUNDS FOR THEIR PREPARING Russian patent published in 2007 - IPC C07D471/04 A61K31/437 A61P1/04 

FIELD: organic chemistry, medicine, pharmacy.

SUBSTANCE: invention relates to imidazopyridine derivatives of the formula (I): that are inhibitors of proton pump. Invention describes compound of the formula (I) or its pharmaceutical acceptable salt wherein Het represents a 5-6-membered aromatic heterocyclic group comprising at least one atom of oxygen or sulfur and substituted with group R³ and group R⁴ at ortho-positions; R¹ represents hydrogen atom (H), -CH₃ or -CH₂OH; R² represents -CH₃ or -CH₂CH₃; R³ and R⁴ are chosen independently from the following group: H, (C₁-C₆)-alkyl, hydroxylated (C₁-C₆)-alkyl; R⁵ and R⁶ are chosen independently from hydrogen atom, (C₁-C₆)-alkyl, hydroxylated (C₁-C₆)-alkyl, (C₁-C₆)-alkoxy-(C₁-C₆)-alkyl, hydroxylated (C₁-C₆)-alkoxy-(C₁-C)-alkyl, either R⁵ and R⁶ can form morpholine or hydroxylated pyrrolidine in common with nitrogen atom to which they are bound; X represents -NH; R¹⁰ represents -CH₂-. Also, invention describes intermediate compounds used for their synthesis. Invention provides preparing novel compounds possessing useful biological properties.

EFFECT: valuable medicinal properties of compounds and medicinal agents.

2 cl, 1 tbl, 23 ex