METHOD FOR PREDICTICTION OF EARLY RECURRENCE OF SUPERFICIAL BLADDER CANCER Russian patent published in 2017 - IPC G01N33/50 

FIELD: medicine.

SUBSTANCE: method including an enzyme immunoassay and immunohistochemical examination of the tumour tissue is described, where the level of matrix metalloproteinase-2 is determined in patients with superficial bladder cancer in the morning urine collected prior to the operation, the ratio of the enzyme to the level of excreted creatinine, as well as in the tumour tissue removed during the operation is calculated, the level of matrix metalloproteinase-2 expression is determined. When the metalloproteinase-2 content is 7.3 pg/mcmol of creatinine and more in urine, and is 52% and more positive cells in the tumour tissue, a high risk of recurrence in a period of 3 to 12 months is predicted.

EFFECT: prediction of the risk of disease recurrence, objective monitoring of malignant process development, a possibility of patients inclusion into risk groups for intensive monitoring, timely measures for appointment of adjuvant treatment.

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