TREATMENT REGIMENS AND METHODS FOR VISUAL FUNCTION IMPROVEMENT IN CASE OF VISION DISORDERS RELATED TO ENDOGENOUS RETINOID DEFICIENCY Russian patent published in 2017 - IPC A61K31/232 A61P27/02 

FIELD: medicine.

SUBSTANCE: first therapeutic dose of the synthetic retinal derivative is administered to a subject with a deficiency of endogenously produced 11-cis-retinal in the form of a divided daily dose over a period of about 2 to about 7 days. Next, a rest period of about 7 to about 28 days is provided. Next, the second therapeutic dose of the synthetic retinal derivative is administered to the said subject at the end of the rest period. The synthetic retinal derivative is selected from 9-cis-retinyl ester or an 11-cis-retinyl ester. The said subject has a decrease in visual function prior to administration of the second therapeutic dose. In other embodiments, methods and a set are provided to improve visual function in a subject having a mutation in the RPE65 or LRAT gene or having an endogenous retinoid deficiency, as well as in a subject with retinitis pigmentosa.

EFFECT: effective improvement of visual function without side effects.

182 cl, 14 dwg, 7 tbl, 6 ex