RETINAL DERIVATIVES AND METHODS OF THEREOF APPLICATION FOR TREATMENT OF VISION IMPAIRMENT Russian patent published in 2015 - IPC C07C403/12 A61F9/07 A61K31/22 A61K31/225 A61P27/02 C07C403/00 A61K31/21 A61P27/00 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention relates to pharmaceutical compositions, in particular to pharmaceutical composition, recovering visual pigment in case of insufficiency of endogenic 11-cis-retinal, which contains effective quantity of retinal derivatives and pharmaceutically acceptable carrier, where retinal derivative is converted into retinal, capable of forming functional complex opsin/retinal, where retinal derivative represents ester of 9-cis-retinyl of formula

ester of 11-cis-retinyl of formula or their combination, where A in each case stands for CH₂OR and R represents ester-forming carboxylate radical of monocarboxylic acid C₁-C₁₀ or polycarboxylic acid, selected from oxalic acid, succinic acid, malic acid, glutaric acid, adipic acid, pimelic acid, suberic acid, azelaic acid, sebacic acid, citric acid, ketoglutaric acid, fumaric acid, malonic acid and oxalacetic acid, which is substituting group in ester, where 11-cis-retinal insufficiency is caused by mutation in genes, coding proteins RPE65 and LRAT.

EFFECT: invention relates to method of recovering photoreceptor function or attenuation of loss of photoreceptor function; and to application of said retinal derivative for drug manufacturing.

43 cl, 7 dwg, 5 ex