FIELD: medicine.
SUBSTANCE: composition for preventing or treating an autoimmune disease comprising antigen-MHC polypeptide complexes function-associated with biocompatible bioadsorbable nanospheres forming a population of nanospheres with polypeptide complexes connected thereto, wherein the ratio of the plurality of polypeptide complexes is greater than 50 to 200 per nanosphere having a size of less than 14 nm. The group of inventions also includes the application of this composition for the treatment of an autoimmune disorder, wherein the composition is administered in an amount sufficient to proliferate antipathogenic autoreactive T-cells. The application of this group of inventions provides significant proliferation of CD8+ T-cells due to the use of antigen-MHC polypeptide complexes associated with biocompatible bioadsorbable nanospheres, wherein a plurality of polypeptide complexes is more than 50 to 200 per nanosphere having a size of less than 14 nm.
EFFECT: directional binding of a plurality of pMHCs to the surface of the nanoparticles through their carboxy-ends results in stabilization of the coated nanoparticles, obtaining a high concentration of particles without disturbing the monodispersity and their stability.
34 cl, 4 ex, 4 tbl, 9 dwg
