METHOD FOR TREATMENT OF ANAL CANCER WITH SKIN TRANSITION Russian patent published in 2017 - IPC A61N7/00 A61N5/10 A61M36/10 A61K31/7064 A61K47/36 A61K35/644 A61K51/00 A61P35/00 

Abstract RU 2638616 C1

FIELD: medicine.

SUBSTANCE: method includes two induction courses of polychemotherapy (PCT) according to the scheme: mitomycin C 10 mg/m2 intravenously sprayed on days 1 and 29 and 5-fluorouracil 1000 mg/m2 per day by continuous infusion on days 1-4 and 29-32. Three weeks after the second course of PCT, the primary focus and regional lymph nodes are exposed to external radiation of 2.4 Gy daily, 5 fractions per week till the cumulative dose of 44 isoGr, 17 irradiation sessions. At that, during 15 irradiation sessions, a sonodynamic therapy session is performed 2 hours before the start of irradiation, for which an "extempore" formulated mixture containing 5 mg of hydrogel napkin "Coletex SP-1" with propolis based on sodium alginate and 100 mg of gemcitabine is delivered to the perianal area skin. After application of the medicinal mixture, a radiator is fed to the lesion focus and a medium frequency ultrasound treatment session is performed at a frequency of 0.88 MHz, I = 1.0 Bm/cm2, exposure time 10 min. On days free from irradiation, no sonodynamic chemotherapy sessions are performed, while 15 procedures of sonodynamic exposure are performed for the entire course of external exposure. The total dose of gemcitabine for the external exposure course is 1500 mg. After the course of irradiation, a break in treatment for 2-3 weeks is performed. Then a course of endovaginal brachytherapy with a fraction dose of 3 Gy with irradiation frequency one day until a cumulative dose of 15 Gy is conducted. On days of irradiation, 2 hours before the irradiation session, a sonodynamic therapy session is performed. For this purpose, the above-mentioned "extempore" composed mixture is introduced into the anus region. Immediately after its delivery, , the radiator is fed to the focal point of the lesion and a medium frequency ultrasonic exposure session is conducted at a frequency of 0.88 MHz, I=1.0 Bm/cm2, exposure time is 10 min. In days free from irradiation, no sonodynamic chemotherapy sessions are performed. A total of 5 procedures are performed for the course of intracavitary irradiation. The total dose of gemcitabine for the course of combined radiation treatment is 2000 mg, total cumulative dose at the primary focus is 61 isoGr.

EFFECT: improved effectiveness of radiation treatment, quality of life of patients with locally advanced anal cancer with transition to the skin, its complete regression.

1 ex, 1 tbl

Similar patents RU2638616C1

Title Year Author Number
METHOD FOR TREATMENT OF BEAM ULCERATIVE PROCTITIS 2015
  • Rozenko Lyudmila Yakovlevna
  • Gusareva Marina Aleksandrovna
  • Fatkina Natalya Borisovna
  • Krokhmal Yuliya Nikolaevna
  • Solntseva Anna Anatolevna
RU2585390C1
METHOD OF COMBINATION TREATMENT OF LOCALLY ADVANCED RECTAL CANCER 2010
  • Afanas'Ev Sergej Gennad'Evich
  • Startseva Zhanna Aleksandrovna
  • Tarasova Anna Sergeevna
RU2447914C1
METHOD FOR THERMOCHEMORADIATION TREATMENT OF RECTAL CANCER 2005
  • Karnaukh Petr Alekseevich
  • Vazhenin Andrej Vladimirovich
  • Pichugin Valentin Semenovich
  • Vaganov Nikolaj Viktorovich
  • Nadvikova Elena Alekseevna
  • Kandakova Elena Jur'Evna
  • Semikopov Konstantin Vladimirovich
RU2294228C1
METHOD OF TREATING SQUAMOUS CELL CANCER OF ANAL CANAL 2011
  • Bojko Anna Vladimirovna
  • Dar'Jalova Sof'Ja L'Vovna
  • Droshneva Inna Viktorovna
  • Sidorov Dmitrij Vladimirovich
  • Zavalishina Larisa Ehduardovna
RU2459644C1
METHOD OF TREATING RECTAL CANCER 2015
  • Rybolovlev Artem Vadimovich
  • Balkanov Andrej Sergeevich
  • Oltarzhevskaya Nataliya Dmitrievna
  • Korovina Mariya Anatolevna
RU2586042C1
METHOD FOR INTEGRATED TREATMENT OF EARLY ANAL SQUAMOUS CELL CARCINOMA 2013
  • Davydov Mikhail Ivanovich
  • Tkachev Sergej Ivanovich
  • Glebovskaja Valerija Vladimirovna
  • Tsarjuk Vladimir Fedorovich
  • Barsukov Jurij Andreevich
  • Timofeev Jurij Mikhajlovich
  • Jazhgunovich Irina Pavlovna
  • Vodjanik Viktorija Viktorovna
  • Zajchenko Oksana Stanislavovna
  • Gutnik Raisa Andreevna
RU2524419C1
METHOD FOR LOCAL RECURRENCE PREVENTION IN PATIENTS SUFFERING LOCALLY ADVANCED BREAST CANCER TNM WITH UNFAVOURABLE PROGNOSTICS 2010
  • Musabaeva Ljudmila Ivanovna
  • Velikaja Viktorija Valer'Evna
  • Zhogina Zhanna Aleksandrovna
  • Lisin Valerij Andreevich
RU2444386C1
METHOD OF INTRACAVITARY THERAPY IN TREATMENT OF PATIENTS WITH CANCER METASTASES INTO VAGINA 2012
  • Rozenko Ljubov' Jakovlevna
  • Dzhabarov Farkhad Rasimovich
  • Frantsijants Elena Mikhajlovna
  • Judina Lina Vasil'Evna
  • Varzer Elena Anatol'Evna
RU2478374C1
METHOD FOR COMBINED NEOADJUVANT POLYCHEMOTHERAPY OF CERVICAL CANCER PATIENTS 2015
  • Moiseenko Tatyana Ivanovna
  • Menshenina Anna Petrovna
  • Nepomnyashshaya Evgeniya Markovna
  • Fatkina Natalya Borisovna
  • Nazaralieva Nelli Albertovna
RU2595855C1
METHOD OF TREATING RECURRENT NON-SMALL CELL LUNG CANCER 2014
  • Zav'Jalov Aleksandr Aleksandrovich
  • Dobrodeev Aleksej Jur'Evich
  • Tuzikov Sergej Aleksandrovich
  • Startseva Zhanna Aleksandrovna
  • Kostromitskij Dmitrij Nikolaevich
RU2558473C1

RU 2 638 616 C1

Authors

Kit Oleg Ivanovich

Rozenko Lyudmila Yakovlevna

Frantsiyants Elena Mikhajlovna

Gusareva Marina Aleksandrovna

Solntseva Anna Anatolevna

Krokhmal Yuliya Nikolaevna

Dates

2017-12-14Published

2016-10-31Filed