METHODS AND COMPOSITIONS FOR TREATING INFLAMMATION AND ISCHEMIC DAMAGE Russian patent published in 2017 - IPC A61K31/145 A61P9/10 A61P43/00 

FIELD: pharmacology.

SUBSTANCE: following are proposed: method for treating a subject suffering from ischemic damage or an acute ischemic event, comprising administering cysteamine, cystamine or a salt thereof, simultaneously with or immediately after the ischemic event, in an amount effective to reduce the ischemic damage, wherein the subject does not suffer from hypercholesterolemia or diabetes of II type, where the administration of cysteamine, cystamine or a salt thereof leads to an increase in adiponectin level with low molecular weight (LMW) (versions) in subjects; a method for increasing (versions) adiponectin levels with LMW in the mentioned patient group comprising contacting the subject with an effective amount of cysteamine, cystamine or a salt thereof (versions); the use of cysteamine, cystamine or a salt thereof in the manufacture of a medicament in the above mentioned treatment of a subject suffering from the acute ischemic event and not suffering from hypercholesterolemia or diabetes of II type.

EFFECT: levels of all adiponectin multimers are increased, within 1 hour after cysteamine exposure in the blood serum, LMW of adiponectin was rapidly and significantly increased, cysteamine administration 2 hours before the ischemic stroke significantly reduced the infarction area and the number of ischemic damages.

28 cl, 18 dwg, 2 tbl, 3 ex