CYSTEAMINE DIOXYGENASE-RESISTANT ANALOGUES OF CYSTEAMINE AND THEIR USE Russian patent published in 2022 - IPC A61K31/145 A61K31/397 A61K31/40 A61K31/4402 A61K31/4409 A61K31/4465 C07D211/54 

Abstract RU 2766579 C2

FIELD: medicine.

SUBSTANCE: invention relates to a method for the treatment of patient suffering from a disease, at which the treatment with cysteamine is prescribed, wherein the disease is a neurological disease or disorder. The method includes the injection to the patient of the effective amount of a composition containing a compound of the formula I or its disulfide, which has a structure selected from the following. In the formulas, R1, R2, R3, R4, R5, R6, R7 and R8 are independently selected from a group consisting of H and C1-5alkyl. The invention also relates to compounds of the first of the specified formulas, where R1 is C1-5alkyl, and R3, R4, R5, R7 and R8 are H, which are used in this method.

EFFECT: proposed method allows for the reduction in cystine levels in patients.

and

6 cl, 1 dwg, 7 tbl, 7 ex

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RU 2 766 579 C2

Authors

Zankel, Todd, C.

Unitt, John

Phillips, Timothy

Gourdet, Benoit

Duffy, Loma

Dates

2022-03-15Published

2016-07-01Filed