FIELD: medicine.
SUBSTANCE: group of inventions can be used to treat heart failure with congestive heart failure (CHF), diabetes or prediabetes in vivo in a patient in need thereof. To this end, a vector is administered to a subject comprising a nucleic acid encoding a paracrine polypeptide or a peptide selected from the group consisting of cardiotonic peptide, urocortin-2 (UCn-2), urocortin-1 (UCn-1), urocortin-3 (UCn-3), brain natriuretic peptide and prostacyclin synthase, wherein the said nucleic acid encoding a paracrine polypeptide or peptide is operably linked to a promoter, wherein the vector is an adeno-associated virus (AAV), and wherein the paracrine polypeptide or peptide is expressed in a cell.
EFFECT: group of inventions provides treatment or improvement of CHF, diabetes or prediabetes in a patient.
24 cl, 20 dwg, 3 tbl
| Title |
Year |
Author |
Number |
| ADENO-ASSOCIATED VIRUS VECTOR |
2015 |
|
RU2743382C2 |
| VIRIONS OF ADENO-ASSOCIATED VIRUS WITH OPTIONAL CAPSID AND METHODS OF THEIR USE |
2012 |
- Sheffer Devid V.
- Klimchak Rajan R.
- Kerber Dzhejms T.
- Flenneri Dzhon Dzh.
- Dalkara Mourot Deniz
- Vizel Majke
- Bern Lea S.T.
|
RU2611202C2 |
| VIRIONS OF AN ADENO-ASSOCIATED VIRUS WITH A VARIANT CAPSID AND METHODS FOR USING THEM |
2017 |
- Sheffer Devid V.
- Klimchak Rajan R.
- Kerber Dzhejms T.
- Flenneri Dzhon Dzh.
- Dalkara Mourot Deniz
- Vizel Majke
- Bern Lea S.T.
|
RU2742724C1 |
| METHODS FOR TREATMENT OF DANON'S DISEASE AND OTHER AUTOPHAGY DISORDERS |
2017 |
- Adler, Eric, D.
- Nelson, Bradley
- Hashem, Sherin
|
RU2777571C2 |
| AAV VECTOR AND NEUTRALIZING ANTIBODIES AGAINST AAV (ADENO-ASSOCIATED VIRUS) ANALYSIS |
2014 |
- Khaj Ketrin A.
- Mingozzi Federiko
- Chen Ifyn
|
RU2705249C2 |
| MODIFIED FACTOR IX, AS WELL AS COMPOSITIONS, METHODS AND OPTIONS FOR THE USE OF GENE TRANSFER INTO CELLS, ORGANS AND TISSUE |
2016 |
- Khaj Ketrin A.
- Angela Khaver
|
RU2811445C2 |
| METHODS FOR ENHANCING BIOLOGICAL ACTIVITY OF RECOMBINANT ADENO ASSOCIATED VIRUS PRODUCED BY BACULOVIRUS SYSTEM |
2017 |
- Zolotukhin, Sergej
- Kondratov, Oleksandr
|
RU2762948C2 |
| COMPOSITIONS, METHODS AND APPLICATIONS OF GENE TRANSFER FOR THE TREATMENT OF NEURODEGENERATIVE DISEASES |
2017 |
- Davidson, Beverly L.
- Chen, Yong Hong
- Tecedor, Luis
|
RU2805606C2 |
| INTRATHECAL ADMINISTRATION OF VECTORS BASED ON ADENO ASSOCIATED VIRUSES FOR GENE THERAPY |
2016 |
- Wilson James M.
- Hinderer Christian
- Rothwell William Thomas
|
RU2775138C2 |
| METHODS AND COMPOSITIONS FOR TREATING AMYLOID DEPOSITS |
2013 |
- Devidson, Beverli, L.
- Khajmen, Bredli, T.
|
RU2673484C2 |
