MEDICINAL DOSAGE FORM, WHICH CONTAINS 6'-FLUOR-(N-METHYL-OR N,N-DIMETHYL)-4-PHENYL-4,9'-DIHYDRO-3'N-SPIRO[CYCLOHEXANE-1,1'-PYRANO[3,4, B]INDOLE]-4-AMINE FOR NEUROPATHIC PAIN TREATMENT Russian patent published in 2017 - IPC A61K31/404 A61K31/35 A61P25/04 A61P29/00 

Abstract RU 2638818 C2

FIELD: pharmacology.

SUBSTANCE: method comprises oral administration of a dosage form containing a pharmacologically active agent according to the general formula wherein R is -H or -CH3, or a physiologically acceptable salt thereof, once a day, to a subject in need thereof. The dosage form provides immediate in vitro release of the pharmacologically active agent, which is contained in a dose of 40 to 190 μg, and the pharmacokinetic parameter tmax is in the range of 4 to 6 hours.

EFFECT: good bioavailability and sufficiency of pain relief, high tolerability and safety.

12 cl, 5 dwg, 15 tbl, 3 ex

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RU 2 638 818 C2

Authors

Gryuning Nadya

Shiller Mark

Fridrikh Ingo

Kerbi Kris

Khemani Ashish

Botmer Jokhn

Sholts Andreas

Dates

2017-12-15Published

2011-08-04Filed