FIELD: pharmacology.
SUBSTANCE: method comprises oral administration of a dosage form containing a pharmacologically active agent according to the general formula wherein R is -H or -CH3, or a physiologically acceptable salt thereof, once a day, to a subject in need thereof. The dosage form provides immediate in vitro release of the pharmacologically active agent, which is contained in a dose of 40 to 190 μg, and the pharmacokinetic parameter tmax is in the range of 4 to 6 hours.
EFFECT: good bioavailability and sufficiency of pain relief, high tolerability and safety.
12 cl, 5 dwg, 15 tbl, 3 ex
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