Show metadata Hide metadata

(19)

(11)

2 727 974

(13)

(51)

IPC

C07D231/12(2006-01-01)

A61K31/496(2006-01-01)

A61P1/12(2006-01-01)

A61P3/04(2006-01-01)

A61P9/08(2006-01-01)

A61P9/10(2006-01-01)

A61P9/12(2006-01-01)

A61P19/02(2006-01-01)

A61P25/06(2006-01-01)

A61P25/08(2006-01-01)

A61P25/14(2006-01-01)

A61P25/24(2006-01-01)

A61P25/28(2006-01-01)

A61P25/30(2006-01-01)

A61P29/00(2006-01-01)

A61P35/00(2006-01-01)

A61P37/00(2006-01-01)

(21) (22)

Application

2018111429, 2016-09-01

(24)

Start date

2016-09-01

(22)

Actual filing date

2016-09-01

(45)

Published

2020-07-28

(72)

Inventor

Torrens-Jover AntoniAlmansa Rosales Carmen

(73)

Holder

Laboratorios Del Dr. Esteve, S.A.

SALTS OF 1-(4-(2-((1-(3,4-DIFLUOROPHENYL)-1N-PYRAZOL-3-YL)METHOXY)ETHYL)PIPERAZIN-1-YL)ETHANONE Russian patent published in 2020 - IPC C07D231/12 A61K31/496 A61P1/12 A61P3/04 A61P9/08 A61P9/10 A61P9/12 A61P19/02 A61P25/06 A61P25/08 A61P25/14 A61P25/24 A61P25/28 A61P25/30 A61P29/00 A61P35/00 A61P37/00

Abstract RU 2727974 C2

FIELD: medicine; pharmaceuticals.

SUBSTANCE: present invention relates to crystalline salts of 1-(4-(2-((1-(3,4-difluorophenyl)-1H-pyrazol-3-yl)methoxy)ethyl)piperazin-1-yl)ethanone, specifically to hydrochloride, maleate, fumarate, malonate, succinate, oxalate and hydrobromide. Invention also relates to a pharmaceutical composition containing said salts, and to use thereof in therapy and/or prevention of sigma-receptor related diseases.

EFFECT: novel crystalline salts which can be used in medicine are obtained and described.

10 cl, 25 dwg, 12 tbl, 9 ex

Similar patents RU2727974C2

Title	Year	Author	Number
PYRAZOLE COMPOUNDS AS SIGMA RECEPTOR INHIBITORS	2011	Garsija Lopes Monika Torrens Khover Antoni Dias Fernandes Khose Luis Kaamano Moure Ana Marija	RU2582338C2
NEW CRYSTALLINE FORM OF 2-{3-[2-(1-{[3,5-BIS(DIFLUOROMETHYL)-1H-PYRAZOL-1-YL]ACETYL}PIPERIDIN-4-YL)-1,3-THIAZOL-4-YL]-4,5-DIHYDRO-1,2-OXAZOL-5-YL}-3-CHLOROPHENYLMETHANE SULPHONATE	2014	Olenik Britta Khillebrand Shtefan Vasner Perr Vajss Martin Vakhendorff-Nojmann Ulrike	RU2691948C2
SIGMA-RECEPTOR INHIBITORS	2005	Laggner Kristian Kuberes-Altisent Marija Rosa Kholents Jorg Berrokal'-Romero Khuana Marija Kontikhoch-L'Obet Marija Montserrat	RU2417987C2
AZOLE DERIVATIVE	2012	Ono Naoja Kuroda Soiti Sirasaki Josikhisa Takajama Tetsuo Sekiguti Josinori Usijama Fumikhito Oka Jusuke	RU2573634C2
SPHINGOSINE-1-PHOSPHATE BINDING INHIBITOR	2007	Ono Naoja Takajama Tetsuo Siozava Fumijasu Katakai Khironori Jabuuti Tetsuja Ota Tomomi Koami Takesi Nisikava Rie	RU2395499C2
PYRAZOL-4-YL-HETEROCYCLYL-CARBOXAMIDE COMPOUNDS AND METHODS FOR APPLICATION	2012	Khodzhz Alaster Dzh. Matteuchchi Mitsio Sharp Endryu San Minkhua Tsui Viki Kh. Van Syaotszin	RU2638552C2
CRYSTALLINE FORM (S)-N-(5-((R)-2-(2,5-DIFLUOROPHENYL)-PYRROLIDIN-1-YL)-PYRAZOLO[1,5-A]PYRIMIDIN-3-YL)-3-HYDROXYPYRROLIDINE-1-CARBOXAMIDE HYDROSULPHATE	2015	Errigo Alisha B. Dzhuengst Derrik Shakh Khalid	RU2723990C2
SALTS OF 4-[2-[[5-METHYL-1-(2-NAPHTHALINYL)-1H-PYRAZOL-3-YL]OXY]ETHYL]MORPHOLINE	2010	Kuberes-Altisent Marija Rosa Sola-Karandel' L'Juis Garsija-Kousejro Urko	RU2559325C2
METHOD FOR PREPARING VORICONAZOLE AND ITS ANALOGUES	2013	Barrel Adam Dzhejms Masgrejv O'Nejl Pedrejg Meri Pettman Alan Dzhon	RU2619928C2
ANTIBACTERIAL COMPOUND NITRATE SALTS	2001	Del' Soldato P'Erro Benedini Francheska Antognatstsa Patritsija	RU2288231C2

RU 2 727 974 C2

Authors

Torrens-Jover Antoni

Almansa Rosales Carmen

Dates

2020-07-28—Published

2016-09-01—Filed