DERIVATIVES OF CIS-TETRAHYDRO-SPIRO(CYCLOHEXANE-1,1'-PYRIDO[3,4-b]INDOLE)-4-AMINE EFFECTIVE IN TREATING NEUROPATHIC AND/OR CHRONIC PAIN Russian patent published in 2016 - IPC C07D471/10 A61K31/438 A61P25/04

Abstract RU 2592283 C2

FIELD: chemistry.

SUBSTANCE: invention relates to derivatives of cis-tetrahydro-spiro(cyclohexane-1,1'-pyrido[3,4-b]indole)-4-amine of formula (III) in form of free bases or physiologically acceptable salts, where R₁ denotes H or CH₃; R₂, R₃, R₄ and R₅ denotes H or halogen. Invention also relates to a pharmaceutical composition based on compound of formula (III), having activity on ORL1 receptor and µ-opioid receptor.

EFFECT: obtaining novel compounds having useful biological properties.

8 cl, 7 tbl, 22 ex

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RU 2 592 283 C2

Authors

Lints Klaus

Tsemolka Zaskia

Nolte Bert

Shunk Shtefan

Shik Khans

Dates

2016-07-20—Published

2011-07-27—Filed