VACCINE Russian patent published in 2017 - IPC A61K39/00 A61K39/385 A61K39/39 A61P3/06 A61P9/00 C12N9/64 

FIELD: biotechnology.

SUBSTANCE: vaccine to reduce cholesterol levels is presented, including two proprotein convertase fragments subtilisin/kexin type 9 (PCSK9), connected to a pharmaceutically acceptable carrier, in which these two fragments are: PEEDGTRFHRQA and SIPWNLERITP; EEDGTRFHRQASK and SIPWNLERITP; EEDGTRFHRQASK and SIPWNLERIT; or EEDGTRFHRQAS and SIPWNLERIT. Application of the specified vaccine for treatment and/or prevention of disorders caused by hyperlipidemia, hypercholesterolemia and/or atherosclerosis, preferably for cardiovascular disease, stroke or peripheral vessels disease is presented.

EFFECT: group of inventions allows to decrease total cholesterol when using these combinations of fragments more efficiently than by using each fragment separately.

8 cl, 2 dwg, 4 tbl, 3 ex