PCSK9 ANTAGONISTS Russian patent published in 2017 - IPC A61K39/395 A61P3/00 A61P9/00 C07K16/40 

FIELD: medicine.

SUBSTANCE: present invention relates to medicine and biotechnology. Application of aqueous composition for preparing drug for reducing blood cholesterol and/or levels of low-density lipoproteins (LDL) in blood and/or reduction of disease incidence or correcting abnormal cholesterol and/or levels of lipoproteins is proposed, caused by disturbed cholesterol metabolism and/or lipoproteins, including hypercholesteremia, dyslipidemia, atherosclerosis, hyperlipidaemia and cardiovascular disease, where said composition contains from approximately 1 mg/ml to approximately 200 mg/ml of antibody-antagonist, which specifically binds with proprotein convertase of subtilisin-kexin type 9 PCSK9; from approximately 1 mm to approximately 100 mm of histidine buffer; from approximately 0.01 mg/ml to approximately 10 mg/ml of polysorbate 80; from approximately 100 mm to nearly 400 mm of trehalose; and from 0.01 mm to approximately 1.0 mm of EDTA disodium dihydrate. Antibody in above composition effectively reduces LDL-cholesterol levels.

EFFECT: in this regard present invention can find further application in therapy of diseases associated with elevated levels of cholesterol-LDL.

6 cl, 24 dwg, 9 tbl, 9 ex