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(19)

(11)

2 698 971

(13)

(51)

IPC

A61K39/00(2006-01-01)

A61K39/385(2006-01-01)

A61K39/39(2006-01-01)

C07K7/00(2006-01-01)

C07K14/435(2006-01-01)

C07K14/195(2006-01-01)

C07K19/00(2006-01-01)

A61P3/06(2006-01-01)

(21) (22)

Application

2016138365, 2015-02-23

(24)

Start date

2015-02-23

(22)

Actual filing date

2015-02-23

(45)

Published

2019-09-02

(72)

Inventor

Galabofa GerganaShtafler GyunterBrunner SilviyaVinzauer GabrieleMairkhofer AndreasYuno Klaudia

(73)

Holder

Affiris Ag

PCSK9 VACCINES Russian patent published in 2019 - IPC A61K39/00 A61K39/385 A61K39/39 C07K7/00 C07K14/435 C07K14/195 C07K19/00 A61P3/06

Abstract RU 2698971 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to biotechnology, specifically to a vaccine for subtilisin-kexin-9 type proteinase (PCSK9), and can be used in medicine for treating or preventing PCSK9 related diseases selected from hyperlipidemia, hypercholesterolemia, atherosclerosis or neoplastic diseases.

EFFECT: conjugate of a variant of PCSK9 fragment with SEQ ID NO: 1 with an immunogenic protein carrier can be used as a part of a vaccine for enhanced induction of PCSK9 antibody formation compared to a natural PCSK9 fragment conjugate.

7 cl, 6 dwg, 2 tbl, 1 ex

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RU 2 698 971 C2

Authors

Galabofa Gergana

Shtafler Gyunter

Brunner Silviya

Vinzauer Gabriele

Mairkhofer Andreas

Yuno Klaudia

Dates

2019-09-02—Published

2015-02-23—Filed