ORAL FILM-FORMING BASIS AND PREPARATION Russian patent published in 2018 - IPC A61K9/46 A61K31/00 A61K47/30 

FIELD: pharmacology.

SUBSTANCE: oral film-forming basis consists of food polymer soluble in water and in organic solvent, with a solubility parameter equal to 9.7-20 (cal/cm³)^1/2, a foam-forming means selected from sodium or ammonium hydrocarbons, or sodium, magnesium, ammonium, potassium or calcium carbonate, and an auxiliary foam-forming means foaming in the presence of water and selected from L-ascorbic acid, potassium L-bitartrate, calcium dihydropyrophosphate, disodium dihydropyrophosphate, galacturonic acid, glucuronic acid, monosodium fumarate, aluminium-potassium sulphate, sodium DL-malate, sodium dihydrophosphate, dipotassium hydrophosphate, sodium dihydrophosphate and disodium hydrophosphate, wherein both foam-forming and auxiliary foam-forming means are not soluble in the specified organic solvent and included in the form of particles with an average size of 0.1 to 60 microns, as well as to the drug, including the medicinal product in the specified basis and to methods for their production.

EFFECT: group of inventions provides a rapid oral dissolution profile and sufficient film strength, reduced stickiness, improved absorption.

17 cl, 47 ex, 13 tbl, 1 dwg