PARTICULATE COMPOSITION AND PROCESS FOR OBTAINING IT Russian patent published in 2018 - IPC A61K9/16 A61K9/14 A61K31/00 A61K47/30 A61K47/04 

FIELD: medicine; pharmaceutics.

SUBSTANCE: present invention describes pharmaceutical particulate composition obtained by spray drying process for slow dissolution of a drug. Composition comprises drug particles, first coating layer applied to the drug particles, and second coating layer covering the first coating layer. Said first coating layer comprises a water-insoluble polymer and inorganic particles or a water-insoluble polymer, inorganic particles and a lipid component. Water-insoluble polymer of the first coating layer contains enteric-soluble cellulose polymer. This lipid component contains C₁₅ or higher molecular weight fatty acid. Average diameter of inorganic particles is from 1.0 to 500 nm. Inorganic particles are composed of silica and/or titanium dioxide and the inorganic particles are contained in amount of 0.5 to 2.4 parts by 2.4 parts by weight of the water insoluble polymer. Second coating layer comprises a water insoluble polymer other than said enteric cellulose polymer.

EFFECT: composition according to invention provides a slow dissolution of the drug.

9 cl, 6 tbl, 24 ex