METHOD FOR PREDICTION OF ESSENTIAL ARTERIAL HYPERTENSION DEVELOPMENT IN CHILDHOOD Russian patent published in 2018 - IPC A61B5/00 

FIELD: medicine.

SUBSTANCE: method includes identification of risk factors, namely: X1-overweight, this indication shall be 1, and the absence of indication is 0; X2 is the total of identified risk factors; X3 is burdened heredity of hypertension, the presence of this indication shall be 1, and the absence is 0; X4 is bearing of 894 NOS3 gene t-allele, the presence of this indication shall be 1, and the lack of sign-0; X5 is pregnancy pathology, the presence of this indication shall be 1, and the absence is 0; X6 is perinatal lesion of the central nervous system (CNS PL) in history, the presence of this indication shall be 1, and the absence is 0; X7 is adverse material conditions of family existence, the presence of this indication shall be 1, and the absence is 0; X8 is low weight at birth, the presence of this indication shall be 1, and the absence is 0; X9 is single-parent family, the presence of this indication shall be 1, and the absence is 0; X10 child smoking, the presence of this indication shall be 1, and the absence is 0; X11 is secondhand smoking (smoking parents), the presence of this indication shall be 1, and the absence is 0; X12 is bearing of 1166 AGTR1 gene C-allele, the presence of this indication shall be 1, and the absence is 0; X13 is combined bearing of CYP11B2 + GNB3 genes polymorphisms, the presence of this indication shall be 1, and the absence is 0; X14 is bearing of 344 gene CYP11B2 T-allele, the presence of this indication shall be 1, and the absence is 0; X15 is bearing of 825 GNB3 gene T-allele, the presence of this indication shall be 1, and the absence is 0; X16 is day regimen violation, the presence of this indication shall be 1, and the absence is 0; X17 is anxious type of child's personality, the presence of this indication shall be 1, and the absence is 0; and classification functions F(1) and F(2) are calculated by the formulas: F(1)=5.99×X1+0.56×X2+15.94×X3+1.90×X4+7.96×X5+4.96×X6+7.21×X+5.91×X8+1.33×X9+4.28×X10-1.24×X11+2.33×X12-13.94×X13+13.93×X14+11.50×X15-0.66×X16-1.92×X17-26.25; F(2) =-8.31×X1+6.56×X2+6.77×X3+4.20×X4+1.22×X5-4.32×X6-0.79×X7-2.35×X8-53.6×X9-5.75×X10-7.23×X11+0.31×X12-21.75×X13+18.52×X14+15.96×X15-5.58×X16-6.20×X17-21.17, if F(1)>F(2), a high risk of early debut of arterial hypertension (up to 18 years) is predicted, if F(1)<F(2), a low risk early debut of arterial hypertension (up to 18 years) is predicted.

EFFECT: invention allows to identify a high-risk group for development of essential hypertension in children and to start timely preventive measures in this category of persons.

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