FIELD: medicine.
SUBSTANCE: control system for patients suffering from diabetes mellitus contains an infusion pump, a glucose sensor and a controller receiving signals from at least one glucose sensor and infusion pump. The controller configuration allows calculation of the rate of basal insulin administration and signals to the infusion pump to deliver the amount of insulin determined by the feedback controller using the predictive model based on the desired glucose concentrations in the patient, the amount of insulin administered and the glucose measurement results for the patient. According to the invention, the controller is configured to set the first lower limiting value of insulin infusion if the controller determines that the patient has started manual bolus insulin delivery within the first time period and the glucose concentration is equal to or higher than the first predetermined threshold. The first lower limiting value of insulin infusion is equal to the calculated rate of basal insulin administration. The controller also has the option of setting the second lower restrictive infusion value to 0 if it is determined that the patient has started manual bolus insulin administration within a period of time and the glucose concentration is not more than or equal to the predetermined threshold. Management based on predictive models determines the amount of insulin for delivery based on the first or second lower limiting infusion value. Management based on predictive models is continuously supported by the system. Alternative methods for diabetes control in a patient are disclosed.
EFFECT: provided management with regard to food intake and manual bolus administration of insulin.
9 cl, 3 dwg
