METHOD AND SYSTEM FOR TUNING CLOSED-LOOP CONTROLLER FOR ARTIFICIAL PANCREAS Russian patent published in 2018 - IPC A61M5/168 A61M31/00 

Abstract RU 2652059 C2

FIELD: medical equipment.

SUBSTANCE: group of inventions relates to medical equipment, specifically to a method for controlling an infusion pump by means of a controller, designed to control the pump and obtain data from a glucose sensor and a diabetes management system. Method comprises obtaining a series of measurements of glucose concentration in a patient. Glucose measurements were taken by a glucose sensor to measure glucose for each time interval from a series of indexed discrete time intervals. Glucose calibration measurement is then taken during the time interval from a series of indexed time intervals to obtain a calibration index. Further, it is determined whether glucose measurement was performed outside the time interval from the series of indexed time intervals to obtain an omission index. Tuning factor is then determined based on both the calibration index and omission index. Amount of insulin administered is then calculated by a controller with control, based on a predictive model. Predictive model uses: the plurality of glucose measurements to predict a trend of the glucose level from estimates of a metabolic state of the patient and the tuning factor so as to provide a calculated insulin amount to be delivered to the patient for each interval of the indexed time interval. System for treating diabetes comprises a glucometer for the occasional measurement of glucose in the patient's blood at time intervals and presentation of a similar occasional blood glucose level in the form of calibration indices for each time interval in the indexed time interval. System also comprises a glucometer for continuous measurement of glucose level in the patient's blood through discrete uniform time intervals and representations of glucose level for each interval in the form of glucose measurement data, in which any omission of glucose measurement through any time interval is stored as an omission index. System comprises an infusion pump for insulin to deliver insulin and a controller, connected to the pump and glycometers. Controller determines the tuning factor based on the calibration index obtained during occasional glucose measurements, and the omission index for the control predictive model. Controller determines the speed of delivery of insulin for each time interval in the indexed time interval from the control predictive model based on the required glucose level.

EFFECT: technical result is the adjustment of the control predictive model based on two variables obtained during continuous glucose monitoring.

7 cl, 4 dwg, 5 tbl

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RU 2 652 059 C2

Authors

Fajnen Deniel

Makkann Tomas

Venugopalan Ramakrishna

Dates

2018-04-24Published

2013-12-05Filed