FIELD: pharmacology.
SUBSTANCE: invention concerns an oral pharmaceutical composition for testosterone shortage treatment for men, containing testosterone undecanoate dissolved in a medium containing at least one lipophilic surfactant and at least one hydrophilic surfactant with a ratio of the total number of lipophilic surfactants to the total number of hydrophilic surfactants (in/out), being in an approximate range from 6:1 to 3.5:1, while the dissolved testosterone undecanoate ranges from 18 to 22 wt % of the composition. The invention also relates to composition application for production of a drug for treatment of testosterone shortage or its symptoms in men and a treatment method, which includes oral intake of an effective amount of the pharmaceutical composition.
EFFECT: application of the invention provides an opportunity to achieve a higher bioavailability, providing an effective therapeutic product based on testosterone for oral introduction, which can increase the levels of testosterone in the blood serum to clinically effective values, efficient oral testosterone therapy.
23 cl, 10 tbl, 5 ex, 5 dwg
