FIELD: medicine; pharmaceuticals.
SUBSTANCE: invention relates to use of a pharmaceutical composition for oral administration in treating a condition associated with testosterone deficiency in a human subject, wherein the composition contains a testosterone ester having a structure
,
in which R is -C13H25O or -C14H27O and one or both esters can be present in the composition, and a pharmaceutically acceptable carrier, wherein the composition is presented in the form of an oral dosage form, wherein the individual being a human is a hypogonadal male, wherein the treatment involves oral administration of the dosage form to a human being in an amount sufficient to provide a daily dose of testosterone ester of 420 to 1250 mg, with the introduction of a single unit of dosing or multiple dosing units, and wherein when administering a single dose to a group of men suffering hypogonadism, said composition provides average serum testosterone concentration Csr t12-t24, which is 35 to 70 % of average serum testosterone concentration Csr t0-t24.
EFFECT: what is presented is using a pharmaceutical composition with improved bioactivity and bioavailability of esters of testosterone in treating a condition associated with testosterone deficiency.
6 cl, 4 dwg, 20 tbl, 9 ex
