FIELD: pharmacology.
SUBSTANCE: present invention relates to a lyophilized (also known as freeze-dried) drug nanosuspension comprising of 4-[[4-[[4-(2-cyanoethenyl)-2,6-dimethylphenyl]amino]-2-pyrimidinyl]amino]benzonitrile or its stereoisomeric form or its pharmaceutically acceptable salt and a steric stabiliser, which is a solid at room temperature, and polyvinyl pyrrolidone.
EFFECT: according to the present invention the composition of the lyophilized drug nanosuspension has an acceptable stability of grain-size composition in storage, including long-term storage.
25 cl, 6 dwg, 7 tbl, 2 ex
| Title | Year | Author | Number |
|---|---|---|---|
| DISPERSIBLE COMPOSITIONS | 2017 |
|
RU2826218C2 |
| POWDERS FOR PREPARING LIQUID DOSAGE FORM | 2008 |
|
RU2477133C2 |
| CRYSTALLINE FORM OF 4-[[4-[[4-(2-CYANOETHENYL)-2,6-DIMETHYLPHENYL]AMINO]-2-PYRIMIDINYL]AMINO]BENZONITRILE | 2008 |
|
RU2498979C2 |
| COMBINATION, ITS APPLICATION AND METHODS FOR TREATMENT USING SPECIFIED COMBINATION | 2018 |
|
RU2755710C2 |
| METHOD FOR PREPARING 4-(1,6-DIHYDRO-6-OXO-2-PYRIMIDINYL)AMINO-BENZONITRILE | 2006 |
|
RU2458056C2 |
| TREATING AND PREVENTING HIV INFECTION | 2010 |
|
RU2569058C2 |
| PHARMACEUTICAL NANOSUSPENSION FOR TREATMENT OF HIV INFECTION | 2017 |
|
RU2665383C1 |
| IMPLANTED DEVICES FOR TREATING HIV | 2009 |
|
RU2546529C2 |
| ANELLATED 9-HYDROXY-1,8-DIOXO-1,3,4,8-TETRAHYDRO-2H-PYRIDO[1,2-A]PYRAZINE-7-CARBOXAMIDES - INTEGRASE INHIBITORS, METHODS FOR PREPARING AND USING THEREOF | 2019 |
|
RU2717101C1 |
| SCHEMES FOR TREATMENT OF HIV-INFECTIONS AND AIDS | 2018 |
|
RU2784810C2 |
