FIELD: chemical-pharmaceutical industry.
SUBSTANCE: group of inventions relates to chemical and pharmaceutical industry and is a pharmaceutical suspension as an injectable preparation for long-term maintenance therapy for HIV infection, comprising compositions comprising, as an active substance, a compound of the general formula 
where R represents C2H5CON-Na+, NH2, or a compound of formula 1b
This composition can be prepared in form of a lyophilisate having a particle size of 200 nm to 900 nm. Also, the invention is represented by a method for preparing the compositions described above, which consists in rotational grinding with zirconium sand in an aqueous solution of a poloxamer of active compounds, solubilizer and detergent, subsequently separating the zirconium sand and lyophilizing the resulting suspension, as well as a method for preparing a pharmaceutical suspension by mixing the claimed composition, phosphate buffered saline solution PBS with pH = 6.8 and water for injection.
EFFECT: invention is an injectable preparation for long-term maintenance therapy.
10 cl, 7 dwg, 3 ex, 5 tbl
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