FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: new product: 8-methoxy-3-(2-morpholinoethylthio)-1,2,4-triazino-[5,6-b] - indole malate. Synthesis is carried out from 2,3-dihydro-1,2,4-triazino-[5,6-b]-indole-3-thione and 2-morpholinoethyl-bromide hydrobromide in the presence of NaOH, at 20 C followed by base treatment with malic acid in the medium of CH3OH at boiling for 15 min. Yield is 92%, m. p. is 212-216 C, empirical formula is C4H6O5•C16H19N5O2S. Compound enhances survival animals under hypoxia condition up to 70% as compared with 50% for 8-methoxy-3-(2-diethylaminoethylthio)-1,2,4-triazino-[5,6-b] -indole and increases myocardium resistance to hypoxia. Synthesized compound can be used in medicine. EFFECT: new compound with enhanced activity. 2 tbl
| Title |
Year |
Author |
Number |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
| 2-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO(6,5-b)INDOL HYDROCHLORIDE POSSESSING ANTIHYPOXIC AND ANTIINFLAMMATORY ACTIVITY |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Poskalenko A.N.
- Ponomareva M.M.
|
SU1014250A1 |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| 3-ETHYLTHIO-5-(2-DIETHYLAMINO)-ETHYL-1,2,4-TRIAZINO(5,6-b)INDOL DIHYDROCHLORIDE POSSESSING ANTIINFLAMMATORY ACTIVITY AND INCREASING RESISTANCE OF ORGANISM TO OXYGEN INSUFFICIENCY |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Poskalenko A.N.
- Ponomareva M.M.
- Basieva T.S.
|
SU1032758A1 |
| 3-(3-DIMETHYLAMINOPROPYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIHYPOXIC ACTIVITY |
1989 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Urjupov O.Ju.
- Kostycheva M.V.
- Smirnov A.V.
|
SU1598431A1 |
| DIHYDROCHLORIDE OF 2-MORPHOLINO-ETHYLTHIO-4,5-DI-(P-CHLOROPHENYL)IMIDAZOLE HAVING ACTIVITY AGAINST HYPOXIA |
1985 |
- Tomchin A.B.
- Vinogradov V.M.
- Khromenkova Z.A.
- Katkov V.F.
|
SU1279212A1 |
| DIHYDROCHLORIDE OF 3-(2-DIMETHYLAMINO)ETHYLAMINO-1,2,4-TRIAZINO(5,6-B)INDOLE IMPROVING RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Makeev B.L.
|
SU1235181A1 |
| HYDROCHLORIDE OF 3-(2-DIETHYLAMINOETHYLAMINO0-1,2,4-TIAZINO/5,6-B/INDOLE INCREASING RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1981 |
- Tomchin A.B.
- Basieva T.S.
- Vinogradov V.M.
- Pastushenkov L.V.
- Urjupov O.Ju.
|
SU978567A1 |
| 3-ETHYLTHIO-5-(2-MORPHOLINO)-ETHYL-1,2,4-TRIAZINO-[5,6-B]-INDOLE HYDROCHLORIDE SHOWING ANTIINFLAMMATORY, ANTIHYPOXIC ACTIVITY AND CAPABILITY TO INCREASE RESISTANCE TO REPEATED CRANIOCEREBRAL TRAUMA |
1982 |
- Tomchin A.B.
- Ponomareva M.M.
- Pastushenkov A.L.
- Gatchina T.A.
- Balljuzek F.V.
- Seleznev L.G.
- Stepnykh Ju.P.
- Pastushenkov V.L.
- Nalimov Ju.D.
- Pastushenkov L.V.
|
SU1059866A1 |
| DIHYDROCHLORIDE OF 8-METHOXY-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE HAVING ACTIVITY AGAINST HYPOXIA AND PROTECTING ACTIVITY AGAINST STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Katkov V.F.
- Urjupov O.Ju.
|
SU1231835A1 |
