FIELD: organic chemistry, heterocyclic compounds. SUBSTANCE: product: 3-(2-dimethylaminoethylthio)-8-methoxy-1,2,4-triazino-[5,6-b] - indole dihydrochloride. Synthesis is carried out from 3-mercapto-1,2,4-triazino-[5,6-b] -indole and 2-dimethylthiaminoethyl-chloride hydrochloride at room temperature followed by treatment with HCl. Empirical formula is C14H17N5OS×2HCl, yield is 42.5%, m. p. is 202 C, LD50 = 580 mg/kg. At hyperthermia new compound at dose 10 mg/kg provides survival in thermochamber (40 C) 75% animals as compared with 30% with known bemithyl. EFFECT: new compound showing enhanced activity. 1 tbl
| Title |
Year |
Author |
Number |
| 3-(2-DIMETHYLAMINOETHYLTHIO)-8-METHYL-1,2,4-TRIAZINO-[5,6-B]- INDOLE DIHYDROCHLORIDE ENHANCING RESISTANCE TO HYPERTHERMIA |
1988 |
- Tomchin A.B.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Kravchenko V.V.
|
SU1547279A1 |
| HYDROCHLORIDE OF 3-(2-DIPROPYLAMINOETHYLTHIO)-1,2,4-TRIAZINO[5,6-B)-INDOLE WHICH INCREASES RESISTANCE AGAINST HYPERTERMIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Zvezdina N.S.
- Vinogradov V.M.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Andreev V.B.
|
SU1483895A1 |
| (1,2,4-TRIAZINO-[5,6-B]-INDOLYL-3-THIO)-ACETIC ACID HYDRAZIDE ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIARRHYTHMIC ACTIVITY |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Alekseev V.V.
- Vinogradov V.M.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Skorobogatov V.I.
|
SU1487415A1 |
| 8-AMINO-3- (2-DIETHYLAMINOETHYLTHIO) -1,2,4-TRIAZINO (5,6-B)- INDOL HYDROCHLORIDE ACCELERATING RECOVERY OF ENCEPHALON FUNCTIONS IN EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Tomchin A.B.
- Grechko A.T.
- Smirnov A.V.
|
SU1786803A1 |
| AMIDE OF (1,2,4-TRIAZINO[5,6-B]INDOLYL-3-THIO)ACETIC ACID WHICH ACCELERATES PROCESSES OF REDUCTION AFTER PHYSICAL LOAD AND HAS ACTIVITY AGAINST HYPOXIA |
1987 |
- Tomchin A.B.
- Zhukova T.I.
- Kuznetsova T.A.
- Vinogradov V.M.
- Spivakova R.P.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1487413A1 |
| DIHYDROCHLORIDE OF 3-(2-DIMETHYLAMINO)ETHYLAMINO-1,2,4-TRIAZINO(5,6-B)INDOLE IMPROVING RESISTANCE OF ORGANISM AGAINST HYPOXIA |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Makeev B.L.
|
SU1235181A1 |
| 3-(2-MORPHOLINOETHYLTHIO)-1,2,4-TRIAZINO-[5,6-B]-INDOLYL-5- ACETAMIDE DIHYDROCHLORIDE ACCELERATING RECOVERY PROCESS AFTER PHYSICAL LOADING, ENHANCING RESISTANCE TO HYPERTHERMIA AND SHOWING ANTIHYPOXIC ACTIVITY |
1987 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Tonkopij D.V.
- Katkov V.F.
- Sumina Eh.N.
- Katkova E.B.
- Urjupov O.Ju.
- Kostycheva M.V.
|
SU1498021A1 |
| HYDROCHLORIDE OF 3-(2-DIMETHYLAMINOETHYLTHIO)-9-METHYL-1,2,4-TRIAZINO(6,5-B)INDOLE WHICH INCREASES PHYSICAL RESISTANCE |
1981 |
- Tomchin A.B.
- Vinogradov V.M.
- Spivakova R.P.
- Basieva T.S.
|
SU1061424A1 |
| DIHYDROCHLORIDE OF 8-METHOXY-3-(2-DIETHYLAMINOETHYLTHIO)-1,2,4-TRIAZINO(5,6-B)INDOLE HAVING ACTIVITY AGAINST HYPOXIA AND PROTECTING ACTIVITY AGAINST STRESS |
1984 |
- Tomchin A.B.
- Vinogradov V.M.
- Basieva T.S.
- Katkov V.F.
- Urjupov O.Ju.
|
SU1231835A1 |
| 8-METHYL-3-(2-MORPHOLINOETHYLTHIO)-5H-1,2,4-TRIAZINO[5,6-B]INDOLE DIHIDROCHLORIDE HYDRATE SHOWING CAPABILITY TO ACCELERATE RECOVERY OF CEREBRUM FUNCTION IN THE EARLY PERIOD AFTER ACUTE MICROWAVE THERMAL STRESS |
1990 |
- Grechko A.T.
- Tomchin A.B.
- Lomov O.P.
- Smirnov A.V.
|
RU1764298C |
