STABLE LIQUID PREPARATION OF ANTIBODY Russian patent published in 2014 - IPC A61K38/00 A61K39/395 A61K31/00 A61K31/198 

FIELD: medicine, pharmaceutics.

SUBSTANCE: invention refers to pharmaceutical preparations of antibodies, particularly to a stable liquid preparation of an antibody, and using the same. The invention represents the liquid preparation of the humanised nerve growth factor (NGF) antibody with the specified amino acid sequence presented in the description, containing both the antibody, and a tonicity agent, particularly trehalose, preferentially trehalose dihydrate, a histidine buffer, a chelating agent presenting EDTA, a surfactant - Polysorbate, preferentially Polysorbate 20 (PS20) taken in certain quantitative proportions. What is described is using the liquid composition of the antibody for preparing a therapeutic agent for treating NGF-mediated inflammatory and pain conditions in a mammal.

EFFECT: composition according to the invention possesses enhanced properties of stably maintaining high concentrations of the bioactive antibody in the solution, providing antibody aggregation, oxidation and fragmentation stability, as well as stable and effective antibody binding.

23 cl, 6 dwg, 16 tbl