PYRAZOLE DERIVATIVES AND THEIR USE AS LPAR5 ANTAGONISTS Russian patent published in 2018 - IPC C07D231/12 C07D409/04 A61K31/415 A61K31/4155 A61P7/02

Abstract RU 2645344 C2

FIELD: chemistry.

SUBSTANCE: present invention relates to compounds of formula (I), wherein residues R¹-R⁵, V, G and M are as defined in the claims. Compounds by the present invention are effective platelet (GPR92) LPAR5 receptor antagonists, and they can generally be used in diseases, at which there is undesirable activation of LPA receptor LPAR5 platelets, LPA receptor LPAR5 mast cells or LPA receptor LPAR5 cells of microglia or for treatment or prevention of which inhibition of LPA receptor of platelet LPAR5, mast cells or microglial cells is expected. Moreover, present invention relates to methods for preparation of compounds of formula (I), their use, in particular as active ingredients in drugs, and to pharmaceutical compositions containing them.

EFFECT: compounds of formula (I) are valuable pharmacologically active compounds for use in the treatment of various diseases, such as cardiovascular disease, like thromboembolic disease or restenosis.

9 cl, 3 tbl, 28 ex

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RU 2 645 344 C2

Authors

Nazare Mark

Kotsian Detlef

Efers Andreas

Chekhtizkij Verngard

Dates

2018-02-21—Published

2013-05-16—Filed