METHOD OF COMPLEX EXTRINSIC FOR PATIENTS WITH ERITHEMATOUS PAPULAR ROSACEA Russian patent published in 2018 - IPC A61K31/4164 A61K31/585 A61P17/10 

FIELD: medicine.

SUBSTANCE: invention relates to medicine, namely, to dermatology, and can be used for extrinsic therapy of moderate form of erythematous papular acne rosacea. Method involves applying to affected five areas: forehead, cheeks, nose and chin, avoiding eye contact, red border of the lips and mucics, a thin layer of Ivermectin cream 1 % (Solantra^®) 1 time per day. Preliminarily skin of face with massage by cubes of frozen decoction of plant products is prepared. Then, extrinsic therapy is performed in two stages: at the first stage, after applying a thin layer of Ivermectin cream 1 % (Solantra^®) in the morning, apply on the same areas of clean skin a thin layer of tacrolimus uncture 0.03 % (Protopik^®) in the evening for 4–6 weeks. At the second stage, with imperfect impact, continue to apply ivermectin cream 1 % (Solantra^®) in the morning for 6 to 8 weeks, and tacrolimus uncture 0.03 % (Protopic^®) are applied once a day 2 times per week for the same period. In this case, ivermectin cream 1 % (Solantra^®) is applied in the morning, and tacrolimus ointment 0.03 % (Protopic^®) is applied in the evening.

EFFECT: use of the invention allows to increase treatment efficacy, reduce evidence of erythema and reduce time of therapy, and prolong disease-free survival.

3 cl, 1 dwg, 2 ex