FIELD: biotechnology.
SUBSTANCE: present invention relates to biotechnology and genetic engineering, namely to process for preparation of ranibizumab with use of new signal sequences for light and heavy chains of ranibizumab, respectively. Present invention also discloses nucleic acids encoding said signal sequences and a light and heavy ranibizumab chain, respectively, vectors and host cells for use in said method.
EFFECT: present invention allows to increase the yield of ranibizumab and to obtain a biologically active protein.
9 cl, 5 dwg, 6 ex
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