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2 648 144

(13)

(51)

IPC

C07K14/745(2006-01-01)

A61K38/36(2006-01-01)

A61P7/04(2006-01-01)

C07K1/18(2006-01-01)

(21) (22)

Application

2016108608, 2014-09-16

(24)

Start date

2014-09-16

(22)

Actual filing date

2014-09-16

(45)

Published

2018-03-22

(72)

Inventor

Jankowski Michael AnthonyJohnson Keith A.Piacenza Wendy CarolRouse Jason C.Shamashkin MichaelSharpe Penelope JaneSwitzer Mary BethWeston Stacey B.

(73)

Holder

Pfizer Inc.

COMPOSITIONS COMPRISING HETEROGENEOUS POPULATIONS OF RECOMBINANT HUMAN CLOTTING FACTOR Xa PROTEINS Russian patent published in 2018 - IPC C07K14/745 A61K38/36 A61P7/04 C07K1/18

Abstract RU 2648144 C2

FIELD: biotechnology.

SUBSTANCE: invention relates to the field of biotechnology, specifically to compositions containing recombinant variants of the human clotting factor Xa, which can be used in medicine. Wide variety of isoforms and post-translational modifications of FXa are obtained recombinantly.

EFFECT: invention provides effective therapy of hemostasis in subjects in need thereof.

37 cl, 7 dwg, 4 tbl, 7 ex

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RU 2 648 144 C2

Authors

Jankowski Michael Anthony

Johnson Keith A.

Piacenza Wendy Carol

Rouse Jason C.

Shamashkin Michael

Sharpe Penelope Jane

Switzer Mary Beth

Weston Stacey B.

Dates

2018-03-22—Published

2014-09-16—Filed